اثر مهارکننده فاکتور رشد عصب ناشی از استرس بر رفتارهای اضطرابی در موش صحرایی

Background and purpose: Nerve growth factor (NGF), as neurotrophin, has a role in response of hypothalamic-pituitary-adrenal axis to stress. In this study, we investigated the role of NGF by inhibiting nerve growth factor anxiety-like behaviors induced by forced swim stress in rats. Materials and methods: In this experimental study, 24 male Wistar rats (200-250 g) were randomly divided into four groups (Control group: vehicle group and treatment groups: 10, 50 and 100 &micro;M of AVG 879 tyrphostin). Intraventricular injection of vehicle and AVG 879 is exerted before force swim stress. Morris water Maze was used to investigate anxiety levels. Data was analyzed by STATISTICA V 5.5 usig ANOVA test. Results: The duration time in closing arm reduced in the group that received AG-879 at low concentrations (10 and 50 &mu;M) (P< 0.05), while it increased in the group that received Tyrphostin at 100 &mu;M (P< 0.05). Also, the time duration in the open arm significantly increased in rats that had AG-879 at 10 and 50 &mu;M, but at 100 &micro;M of the drug this parameter decreased (P< 0.05). Conclusion: Exposure to stress increased anxiety-related behavior. Compared with the control group, anxiety-like behaviors reduced in the groups that received nerve growth factor inhibitor.